Diltiazem in familial primary hyperhidrosis
Several members of a family suffering from an apparent autosomal dominant form of primary focal hyperhidrosis had a marked reduction in sweat output with the use of the calcium channel blocker diltiazem. Studies have suggested that sweat output is, in part, initiated by an influx of calcium from the extracellular space into the secretory cells of the eccrine gland. Calcium channel blockers prevent the influx of calcium across cell membranes and, thus, may be useful in hyperhidrosis. A search of the medical literature using PubMed, however, found no further published reports of calcium channel blockers in the treatment of hyperhidrosis.