Diltiazem in familial primary hyperhidrosis

Several members of a family suffering from an apparent autosomal dominant form of primary focal hyperhidrosis had a marked reduction in sweat output with the use of the calcium channel blocker diltiazem.[66] Studies have suggested that sweat output is, in part, initiated by an influx of calcium from the extracellular space into the secretory cells of the eccrine gland.[118] Calcium channel blockers prevent the influx of calcium across cell membranes and, thus, may be useful in hyperhidrosis. A search of the medical literature using PubMed, however, found no further published reports of calcium channel blockers in the treatment of hyperhidrosis.