Systemic Medication: Clonidine

Clonidine is a centrally active alpha-2 receptor agonist that decreases norepinephrine release.[79] One small case series and several case reports have been published regarding its effect on hyperhidrosis. Clonidine reduced sweating in 2 women with paroxysmal localized hyperhidrosis, a rare condition that can be idiopathic, can be due to nervous system disease, or can occur as a manifestation of gustatory sweating.[79] The medication was also found to be helpful for 12 patients with the same diagnosis in a French case series. (Rev Neurol) A patient with excessive sweating due to tricyclic antidepressant use had marked reduction in sweating with clonidine.[36] In another report, a man with anxiety-induced facial and scalp hyperhidrosis found relief with the combination of clonidine and topical aluminum chloride.[146] Lastly, clonidine has been reported helpful in a case of gustatory hyperhidrosis. (Archives of Physical Med Rehab)