Published Scientific Research

It's vital to review published clinical data when discussing or reporting on health and hyperhidrosis. Further, we strongly encourage product and treatment development teams to conduct rigorous testing and to espouse only that which can be validated.

The articles, posters, and study data provided chronologically below represents the best peer-reviewed medical and scientific information to date regarding the physiology, treatment, and effects of hyperhidrosis. New data and results will be posted as they become available. Use this rich library of research to inform your decisions and perceptions.

If you know of published scientific information that should be included here, please let us know.

2014 studies

Boschert, Sherry.  "Laser therapy improved severe hyperhidrosis."  Skin & Allergy News, 30 April 2014.  Web.

Pinson, Igor MD, PhD, et al.  “Non-invasive short-wave guided radiofrequency device for long-term sweat reduction in patients with primary axillary hyperhidrosis:  a preliminary study”, presented at the 34 ASLMS Annual Conference, April 4-6, 2014, Phoenix, AZ.

2013 studies

de Menezes Lyra, Roberto.  “Visual scale for the quantification of hyperhidrosis”.  J. bras. Pneumol 39:4 (2013). 

Fatemi, Afshin.  “Apparatus for the treatment of hyperhidrosis”.  Patent EP 2645954 A1.  9 October 2013.

Patakfalvi, Laura & Benohanian, Antranik.  “Treatment of palmar hyperhidrosis with needle-free injection of botulinum toxin A”.  Arch Dermatol Res doi:  10.1007/s00403-013-1425-7.  Published online November 7, 2013.

Gordon, Jennifer R.S. & Hill, Samantha E.  "Update on pediatric hyperhidrosis".  Dermatologic Therapy 26 (2013):  452-461.

Lee, Sang-jun, et al.  “The efficacy of a microwave device for treating axillary hyperhidrosis and osmidrosis in Asians:  a preliminary study”.  J Cosmet Laser Ther 15:5 (2013):  255-259. (Abstract Only)

Jacob, Carolyn MD.  “Treatment of hyperhidrosis with microwave technology”.  Seminars in Cutaneous Medicine and Surgery 32 (2013):  2-8.

Rokhsar, Cameron & Kim, Min Jeong. "A retrospective analysis of the treatment of axillary hyperhidrosis with a novel microwave technology", presented at the 33rd ASLMS Annual Conference, April 3-7, 2013, Boston, MA. (Abstract Only)

Biehle-Hulette, Susan J. PhD, et al. “Significant protection from event sweat – without a prescription”, presented at the American Academy of Dermatology 71st Annual Meeting, March 1-5, 2013, Miami Beach, FL .

Scarff, Jonathan R. MD. "Options for treating antidepressant-induced sweating". Current Psychiatry 12:1 (2013): 51.

2012 studies

Glaser, Dee Anna MD, et al. "A randomized, blinded clinical evaluation of a novel microwave device for treating axillary hyperhidrosis: the dermatologic reduction in underarm perspiration study". Dermatol Surg 38 (2012): 185-191.

Johnson, Jessi PhD, et al.  “Microwave thermolysis of sweat glands”.  Lasers in Surgery and Medicine 44:1 (2012):  20-25.  (Abstract Only)

Lupin, Mark MD, FRCPC and Hong, Chih-ho MD, FRCPC.  “Clinical evaluation of a microwave treatment for axillary hyperhidrosis:  long-term follow-up”, presented at the American Society for Dermatologic Surgery 2012 Annual Meeting, October 11-14, 2012, Atlanta, GA.  (Abstract Only)

Wolosker, Nelson MD, PhD, et al. "A randomized placebo-controlled trial of oxybutynin for the initial treatment of palmar and axillary hyperhidrosis". Journal of Vascular Surgery 55:6 (2012): 1696-1700.

Paller, Amy S. MD, et al. "Oral glycopyrrolate as second-line treatment for primary pediatric hyperhidrosis". J Am Acad Dermatol 67:5 (2012): 918-923.

Rubin, Denis, et al. “Second-hand stress: inhalation of stress sweat enhances neural response to neutral faces”. Soc Cogn Affect Neurosci 7:2 (2012): 208-212.

Kerscher, Martina, et al. "Comparison of the spread of three botulinum toxin type A preparations". Arch Dermatol Res 304 (2012): 155-161.

Kayser, SC, et al. “Perioral gustatory sweating: case report”. The Journal of Laryngology & Otology 126 (2012): 532-534.

Hill, Samantha MD & Glade, Danielle MS. “Hyperhidrosis – a review of primary hyperhidrosis and its current management”. Clinical Dermatology 6:2 (2012): 19-24.

Hong, H. Chih-Ho MD, FRCPC, et al. “Clinical evaluation of a microwave device for treating axillary hyperhidrosis”. Dermatol Surg doi: 10.1111/j.1524-4725.2012.02375.x. Published online March 27, 2012.

Walling, Hobart W. MD, PhD. “Systemic therapy for primary hyperhidrosis: a retrospective study of 59 patients treated with glycopyrrolate or clonidine”. J Am Acad Dermatol 66:3 (2012): 387-392.

Wolosker, Nelson MD, et al. “Evaluation of quality of life over time among 453 patients with hyperhidrosis submitted to endoscopic thoracic sympathectomy”. Journal of Vascular Surgery 55:1 (2012): 154-156.

Salvaggio, Heather L. MD & Wagner, Annette M. MD. “Suture boots: an aid for the injection of onabotulinum toxin A for primary focal hyperhidrosis”. Pediatric Dermatology doi: 10.1111/j.1525-1470.2012.01849.x. Published online September 7, 2012.

Swaile, D.F., et al. “Clinical studies of sweat rate reduction by an over-the-counter soft-solid antiperspirant and comparison with a prescription antiperspirant product in male panelists”. Br J Dermatol 166 Suppl. 1 (2012): 22-26.

2011 studies

Smith, Stacy R. MD.  “Evolution of a new treatment modality for primary focal hyperhidrosis”, presented at Cosmetic Boot Camp 2011, June 14-17, 2011, Aspen, CO.

Martin, A, et al. “Effective prevention of stress-induced sweating and axillary malodour formation in teenagers”. Int J Cosmet Sci 33:1 (2011): 90-97. (Abstract Only)

Wang, Fei-ge, et al. “Comparison of compensatory sweating and quality of life following thoracic sympathetic block for palmar hyperhidrosis: electrocautery hook versus titanium clip”. Chinese Medical Journal 124:21 (2011): 3495-3498.

Atkinson, John L.D. MD, et al. “Endoscopic transthoracic limited sympathotomy for palmar-plantar hyperhidrosis: outcomes and complications during a 10-year period”. Mayo Clin Proc 86:8 (2011): 721-729.

Walling, HW and Swick, BL. “Treatment options for hyperhidrosis”. Am J Clin Dermatol 12:5 (2011): 285-295.

Wolosker, Nelson, et al. “The use of oxybutynin for treating axillary hyperhidrosis”. Annals of Vascular Surgery 25:8 (2011): 1057-1062.

Woolery-Lloyd, Heather MD & Valins, Whitney MD. “Aluminum chloride hexahydrate in a salicylic acid gel base: a case series of combination therapy with botulinum toxin type A for moderate to severe hyperhidrosis”. Cutis 88:1 (2011): 43-45.

Milanez de Campos, Jose Ribas, et al. “Is age group a predictive factor for satisfaction among patients undergoing sympathectomy to treat hyperhidrosis”? J Vasc Bras 10:4 (2011): 284-288.

Wolosker, Nelson, et al. “The use of oxybutynin for treating facial hyperhidrosis”. An Bras Dermatol 86:3 (2011): 451-456.

Doft, MA, et al. "Treatment of axillary hyperhidrosis with botulinum toxin: a single surgeon's experience with 53 consecutive patients". Aesthetic Plast Surg 2011 May 11. (Abstract Only)

Lupin, Mark, et al. "A multi-center evaluation of the miradry system to treat subjects with axillary hyperhidrosis", presented at the 31st ASLMS Annual Conference, April 1-3, 2011, Grapevine, TX.

Kilmer, Suzanne, et al. "A randomized, blinded clinical study of a microwave device for treatment of axillary hyperhidrosis", presented at the 31st ASLMS Annual Conference, April 1-3, 2011, Grapevine, TX.

2010 studies

Wait, Scott D., et al.  “Thoracoscopic sympathectomy for hyperhidrosis:  analysis of 642 procedures with special attention to horner’s syndrome and compensatory hyperhidrosis”.  Neurosurgery 67:3 (2010):  652-657.

Kaminer, Michael S. MD, et al.  “First clinical use of a novel microwave device for treatment of axillary hyperhidrosis”, presented at the American Society for Dermatologic Surgery 2010 Annual Meeting, October 21-24, 2010, Chicago, IL. 

Marques, Andrea H., et al. “Evaluation of stress symptoms by applying noninvasive methodologies: measurements of neuroimmune biomarkers in the sweat, heart rate variability and salivary cortisol”. Neuroimmunomodulation 17:3 (2010): 205-208.

Dressler, Dirk. "Comparing Botox® and Xeomin® for axillar hyperhidrosis”. J Neural Transm 117 (2010): 317-319.

Cantarella, Giovanna MD, et al. “Treatment of Frey’s syndrome with botulinum toxin B”. Otolaryngol Head Neck Surg 143 (2010): 214-218.

Glaser, Dee Anna, MD, et al. "A randomized, blinded clinical evaluation of a novel microwave device for treatment of axillary hyperhidrosis", presented at the 2010 ASDS/ASCDAS Joint Annual Meeting, October 21-24, 2010, Chicago, IL.

Hill, Samantha MD. (Fall 2010). "Hyperhidrosis Diagnosis and Management". Pediatric Rounds, a newsletter from the physicians of Children's Specialty Group, 12-14.

Shams, Kave MBChB, MRCP & Kavanagh, Gina M. MBChB, MRCP. "Immediate reduction in sweat secretion with electric current application in primary palmar hyperhidrosis". Archdermatol doi: 10.1001/archdermatol.2010.300. Published online October 18, 2010.

Bellet, JS. “Diagnosis and treatment of primary focal hyperhidrosis in children and adolescents”. Semin Cutan Med Surg 29:2 (2010): 121-126.

Prasad, Arun, et al. "Endoscopic thoracic sympathectomy for primary palmar hyperhidrosis". Surg Endosc 24 (2010): 1952-1957.

Milanez de Campos, Jose Ribas, et al. “Comparison of pain severity following video-assisted thoracoscopic sympathectomy: electric versus harmonic scalpels”. Interactive Cardiovascular and Thoracic Surgery 10 (2010): 919-922.

Wolosker, Nelson, et al. “Is gender a predictive factor for satisfaction among patients undergoing sympathectomy to treat palmar hyperhidrosis”? Clinics 65:6 (2010): 583-586.

Wolosker, Nelson, MD, PhD, et al. “Quality of life before surgery is a predictive factor for satisfaction among patients undergoing sympathectomy to treat hyperhidrosis”. Journal of Vascular Surgery 51:5 (2010): 1190-1194.

2009 studies

Kim, Won Oak MD, et al.  “Botulinum toxin:  a treatment for compensatory hyperhidrosis in the trunk”.  Dermatol Surg 35:5 (2009):  833-838.  (Abstract Only)

Mujica-Parodi, Lilianne R., et al. “Chemosensory cues to conspecific emotional stress activate amygdale in humans”. PLoS One doi: 10.1371/journal.pone.0006415. Published online July 29, 2009.

Prehn-Kristensen, A, et al. “Induction of empathy by the smell of anxiety”. PLoS One doi: 10.1371/journal.pone.0005987. Published online June 24, 2009.

Scully, C, et al. “Marathon of eponyms: 6 Frey syndrome (gustatory sweating)”. Oral Diseases 15 (2009): 608-609.

de Bree, Remco MD, PhD, et al. “Repeated botulinum toxin type A injections to treat patients with Frey syndrome”. Arch Otolaryngol Head Neck Surg 135:3 (2009): 287-290.

Ng, Samson, et al. “Management of Frey syndrome using botulinum neurotoxin: a case report”. JCDA 75:9 (2009): 651-654.

Baron, Jennifer A. MD & Zloty, David M. MD. “Bilateral type 1 complex regional pain syndrome after local nerve blocks for palmar hyperhidrosis”. Dermatol Surg 35 (2009): 885-887.

Mahendiran, Shavitri, et al. "Hyperhidrosis: a review of a medical condition". The Open Dermatology Journal 3 (2009): 195-197.

Flanagan, Katherine H. MD & Glaser, Dee Anna MD. “An open-label trial of the efficacy of 15% aluminum chloride in 2% salicylic acid gel base in the treatment of moderate-to-severe primary axillary hyperhidrosis”. Journal of Drugs in Dermatology 8:5 (2009): 477-480.

Jones, Terry MD, et al. "Safety and tolerability of topical botulinum toxin type A in healthy adults", presented at the 69th Annual Meeting of the Society for Investigative Dermatology, May 2009, Montreal, Canada.

“American Academy of Dermatology Responds to FDA Decision Regarding Botulinum Toxin Products”, Schaumburg, IL, April 2009.

Walling, Hobart W. MD, PhD. “Primary hyperhidrosis increases the risk of cutaneous infection: a case-control study of 387 patients”. J Am Acad Dermatol doi: 10.1016/j.jaad.2009.02.038. Published online April 24, 2009.

Keller, Steven M., et al. “Diagnosis of palmar hyperhidrosis via questionnaire without physical examination”. Clin Auton Res doi: 10.1007/s10286-009-0006-5. Published online April 16, 2009.

Goldman, A & Wollina, U. "Subdermal Nd-YAG laser for axillary hyperhidrosis". Dermatol Surg 35:6 (June 2009):1018 (Abstract Only)

Grunfeld, Alexander, et al. “Botulinum toxin for hyperhidrosis”. Am J Clin Dermatol 10:2 (2009): 87-102.

Miller, Daniel L. MD, et al. “Effect of sympathectomy level on the incidence of compensatory hyperhidrosis after sympathectomy for palmar hyperhidrosis”. J Thorac Cardiovasc Surg 138 (2009): 581-585. (Abstract Only)

Cruz, Jorge MD, PhD, et al. “Effects of endoscopic thoracic sympathectomy for primary hyperhidrosis on cardiac autonomic nervous activity”. The Journal of Thoracic and Cardiovascular Surgery 137:3 (2009): 664-669.

Chow, A & Wilder-Smith, E.P. “Effect of transdermal botulinum toxin on sweat secretion in subjects with idiopathic palmar hyperhidrosis”. Br J Dermatol 160:3 (2009): 721-722.

2008 studies

Kim, WO, et al. “Topical glycopyrrolate for patients with facial hyperhidrosis.” Br J Dermatol 158 (2008): 1094-1097. (Abstract Only)

Laing, T.A., et al. “Botulinum toxin for treatment of glandular hypersecretory disorders”. Journal of Plastic, Reconstructive & Aesthetic Surgery 61 (2008): 1024-1028.

Bahmer, Friedrich A. MD & Sachse, Michael M. MD. “Hyperhidrosis area and severity index”. Dermatol Surg 34 (2008): 1744-1745.

Gelbard, Christina M. MD, et al. “Primary pediatric hyperhidrosis: a review of current treatment options”. Pediatric Dermatology 25:6 (2008): 591-598.

Kossintseva, Iren & Barankin, Benjamin. “Improvement in both raynaud disease and hyperhidrosis in response to botulinum toxin type A treatment”. Journal of Cutaneous Medicine and Surgery 12:4 (2008): 189-193.

Efthymiou, Christopher Andrew & Thorpe, James Andrew Charles. “Compensatory hyperhidrosis: a consequence of truncal sympathectomy treated by video assisted application of botulinum toxin and reoperation”. European Journal of Cardio-thoracic Surgery 33 (2008): 1157-1158.

Hartl, DM, et al. “Botulinum toxin A for quality of life improvement in post-parotidectomy gustatory sweating (Frey’s syndrome)”. The Journal of Laryngology & Otology 122 (2008): 1100-1104.

Honeyman, JF, et al. “Efficacy of botulinum toxin for a congenital eccrine naevus”. J Eur Acad Dermatol Venereol 22:10 (2008): 1275-1276.

Munia, Marco Antonio S, et al. “Sustained benefit lasting one year from T4 instead of T3-T4 sympathectomy for isolated axillary hyperhidrosis”. Clinics 63:6 (2008): 771-774.

Flanagan, Katherine H. MD, et al. “Botulinum toxin type A versus topical 20% aluminum chloride for the treatment of moderate to severe primary focal axillary hyperhidrosis”. Journal of Drugs in Dermatology 7:3 (2008): 221-227.

Smalls, Lola Kelly PhD, MBA, et al. “Clinical comparison of otc products labeled prescription strength wetness protection to prescription antiperspirants”, presented at the 66th Annual Meeting of the American Academy of Dermatology, February 1-5, 2008, San Antonio, TX.

Smalls, Lola Kelly PhD, MBA, et. al. “Chromophore mapping of hemoglobin for the assessment of axillary irritation: comparison of otc and prescription antiperspirants”, presented at the 66th Annual Meeting of the American Academy of Dermatology, February 1-5, 2008, San Antonio, TX.

Cheshire, William P. Jr. & Fealey, Robert D. "Drug-induced hyperhidrosis and hypohidrosis". Drug Safety 31:2 (2008): 109-126.

2007 studies

Pomprasit, Mattanee MD & Chintrakam, Chalermchai MD. “Treatment of Frey’s syndrome with botulinum toxin”. J Med Assoc Thai 90:11 (2007): 2397-2402.

de Bree, Remco MD, PhD, et al. “Management of Frey syndrome”. Head & Neck 29:8 (2007): 773-778.

Na, Gun Yoen MD, et al. "Control of palmar hyperhidrosis with a new 'dry-type' iontophoretic device". Dermatol Surg 33 (2007): 57-61.

Solish, Nowell MD, FRCPC, et al. “A comprehensive approach to the recognition, diagnosis, and severity-based treatment of focal hyperhidrosis: recommendations of the canadian hyperhidrosis advisory committee". Dermatol Surg 33 (2007): 908-923.

Bechara, Falk G. MD, et al. “Focal hyperhidrosis of the anal fold: successful treatment with botulinum toxin A”. Dermatol Surg 33 (2007): 924-927.

NAD Examines Advertising for P&G's 'Secret Clinical Strength,' National Advertising Review Council, New York, NY, July 2007.

Glaser, Dee Anna MD, et al. “Primary focal hyperhidrosis: scope of the problem”. Cutis 79:suppl 5 (2007): 5-17.

Glaser, Dee Anna MD, et al. “Palmar and plantar hyperhidrosis: best practice recommendations and special considerations”. Cutis 79:suppl 5 (2007): 18-28.

Glaser, Dee Anna MD, et al. “Facial hyperhidrosis: best practice and recommendations and special considerations”. Cutis 79:suppl 5 (2007): 29-32.

Ram, Ramin MD, et al. “Current and emerging therapeutic modalities for hyperhidrosis, part 2: moderately invasive and invasive procedures”. Cosmetic Dermatology 79 (2007): 281-288.

Glaser, Dee Anna MD, et al. “Functional and dermatology-specific quality of life benefits with repeated botulinum toxin type A treatment of primary axillary hyperhidrosis over 4 years”, presented at the 65th Annual Meeting of the American Academy of Dermatology, February 2-6, 2007, Washington, DC.

Kessler, Edward, B.A., et al. “A demographical study of hyperhidrosis”, presented at the 65th Annual Meeting of the American Academy of Dermatology, February 2-6, 2007, Washington, DC.

Glaser, Dee Anna MD, et al. “4-Year longitudinal data on the efficacy and safety of repeated botulinum toxin type A therapy for primary axillary hyperhidrosis”, presented at the 65th Annual Meeting of the American Academy of Dermatology, February 2-6, 2007, Washington, DC.

Thomas, Mike BS, MBA, et al. “Alternative topical treatment to an aluminum chloride antiperspirant that provides prescription strength efficacy with significantly less irritation”, presented at the 65th Annual Meeting of the American Academy of Dermatology, February 2-6, 2007, Washington, DC.

Munia, Marco Antonio S, et al. “A randomized trial of T3-T4 versus T4 sympathectomy for isolated axillary hyperhidrosis”. Journal of Vascular Surgery 45:1 (2007): 130-133.

Aghaei, Shahin MD. “Botulinum toxin therapy for palmar hyperhidrosis: experience in an Iranian population”. The International Society of Dermatology 46 (2007): 212-214.

Lear, William BSC, MD, et al. “An epidemiological study of hyperhidrosis”. Dermatol Surg 33 (2007): S69-S75.

Talarico-Filho, Sergio MD, et al. “A double-blind, randomized, comparative study of two type A botulinum toxins in the treatment of primary axillary hyperhidrosis”. Dermatol Surg 33 (2007): S44-S50.

Glogau, Richard G. MD. "Topically applied botulinum toxin type A for the treatment of primary axillary hyperhidrosis: results of a randomized, blinded, vehicle-controlled study". Dermatol Surg 33 (2007): S76-S80.

2006 studies

Izadi, Shahrnaz MBChB, BSc Hons, et al.  "Mydriasis and accommodative failure from exposure to topical glycopyrrolate used in hyperhidrosis".  J Neuroophthalmol 26 (2006):  232-233.  (Abstract Only)

Santini, M, et al.  "Suture hook technique for thoracoscopic sympathectomy for severe hyperhidrosis", presented at the XXXV World Congress of the International College of Surgeons, October 25-29, 2006, Pattaya, Thailand

Glaser, Dee Anna. “The use of botulinum toxins to treat hyperhidrosis and gustatory sweating syndrome”. Neurotoxicity Research 9:2-3 (2006): 173-178.

Dressler, Dirk & Eleopra, Roberto. “Clinical use of non-A botulinum toxins: botulinum toxin type B”. Neurotoxicity Research 9:2-3 (2006): 121-125.

Khoo, SG, et al. “The use of botulinum toxin in Frey’s syndrome”. IMJ 99:5 (2006): 136-137.

Bakke, Merete, et al. “Treatment of gustatory sweating with low-dose botulinum toxin A”. Acta Odontologica Scandinavica 64:3 (2006): 129-133.

Lim, Erle C.H., et al. “Topical botulinum toxin to treat hyperhidrosis? No sweat!” Medical Hypotheses 67 (2006): 27-32.

Milanez de Campos, Jose Ribas, et al. “Axillary hyperhidrosis: T3/T4 versus T4 thoracic sympathectomy in a series of 276 cases”. Journal of Laparoendoscopic & Advanced Surgical Techniques 16:6 (2006): 598-603.

Barankin, Benjamin MD, et al. “Treatment of inguinal hyperhidrosis with botulinum toxin type A”. International Journal of Dermatology 45 (2006): 985-986.

Kavanagh, Gina M. MD & Shams, Kave MD. “Botulinum toxin type A by iontophoresis for primary palmar hyperhidrosis”. Journal of the American Academy of Dermatology 55:5 (2006): S115-S117.

Kavanagh, G.M., et al. “Topical glycopyrrolate should not be overlooked in treatment of focal hyperhidrosis”. British Journal of Dermatology 155:2 (2006): 487.

Pariser, David MD, et al. “Effect of botulinum toxin type A treatment for severe primary axillary hyperhidrosis on work performance and productivity: results from an open-label clinical study”, presented at the 64th Annual Meeting of the American Academy of Dermatology, March 3-7, 2006, San Francisco, CA.

Thomas, Mike MBA, et al. “Panel discussions among hyperhidrosis patients to assess lifestyle limitations, treatment regimes, and compensating behaviors”, presented at the 64th Annual Meeting of the American Academy of Dermatology, March 3-7, 2006, San Francisco, CA.

Hamm, Henning, et al. "Primary focal hyperhidrosis: disease characteristics and functional impairment". Dermatology 2006 212 (2006): 343-353.

Moya, J., et al.“Thoracic sympathicolysis for primary hyperhidrosis”. Surg Endosc 20 (2006): 598-602.

2005 studies

Ogata, A, et al. “Low and high frequency acupuncture stimulation inhibits mental stress-induced sweating in humans via different mechanisms”. Auton Neurosci 118: 1-2 (2005): 93-101. (Abstract Only)

Glaser, Dee Anna MD, et al. “Efficacy and safety of repeated botulinum toxin type A treatment for primary axillary hyperhidrosis: 12-month interim analysis of a multicenter, open-label trial”, presented at ACADEMY ’05 American Academy of Dermatology Summer Meeting, July 20-24, 2005, Chicago, IL.

Kowalski, Jonathan W. PharmD, MS, et al. “Cost-effectiveness and budget impact of botulinum toxin type A (BoNTA) treatment for severe primary axillary hyperhidrosis inadequately managed with topical agents”, presented at ACADEMY ’05 American Academy of Dermatology Summer Meeting, July 20-24, 2005, Chicago, IL.

Neumayer, Christoph MD, et al. "Effect of endoscopic thoracic sympathetic block on plantar hyperhidrosis". Arch Surg 140: 676-680 (2005).

Eisenach, John H. MD, et al. “Hyperhidrosis: evolving therapies for a well-established phenomenon”. Mayo Clinic Proceedings 80:5 (2005): 657-666.

Solish, Nowell MD, et al. “Prospective open-label study of botulinum toxin type A in patients with axillary hyperhidrosis: effects on functional impairment and quality of life”. Dermatol Surg 31:4 (2005): 405-413.

Cliff, Sandeep H. FRCP & Reeken, Saskia. “Axillary hyperhidrosis and botox responding to demands: starting a nurse-led service”. Nurse2Nurse 5:1 (2005): 28-30.

Krogstad, AL, et al. "No compensatory sweating after botulinum toxin treatment of palmar hyperhidrosis". Br J Dermatol 152:2 (Feb 2005): 329-333. (Abstract Only)

Haider, Aamir & Solish, Nowell.“Focal hyperhidrosis: diagnosis and management”. CMAJ 172:1 (2005): 1-7.

2004 studies

Dickerson, SS & Kemeny, ME. “Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research”. Psychol Bull 130:3 (2004): 355-391. (Abstract Only)

Lowe, N, et al. "The place of botulinum toxin type A in the treatment of focal hyperhidrosis". Br J Dermatol 151:6 (Dec 2004): 1115-1122. (Abstract Only)

Lee, Jae-Bong MD, et al. “A case of foul genital odor treated with botulinum toxin A”. Dermatologic Surgery doi: 10.1111/j.1524-4725.2004.30382.x. Published online September 1, 2004. (Abstract Only)

Campanati, Anna MD, et al. “Local neural block at the wrist for treatment of palmar hyperhidrosis with botulinum toxin: technical improvements”. Journal of the American Academy of Dermatology 51:3 (2004): 345-348.

Strutton, David R. PhD, MPH, et al. “US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey”. Journal of the American Academy of Dermatology 51:2 (2004): 241-248.

Hornberger, John MD, MS, et al. “Recognition, diagnosis, and treatment of primary focal hyperhidrosis”. Journal of the American Academy of Dermatology 51:2 (2004): 274-286.

Glaser, DA, et al. “Botulinum toxin type A improves occupational impairment associated with primary axillary hyperhidrosis and results in high levels of satisfaction with treatment”, presented at the American Academy of Dermatology Summer Meeting, July 28- August 1, 2004, New York, NY.


Carruthers, Alastair MD & Carruthers, Jean MD. “Long-term safety review of subjects treated with botulinum toxin type A for cosmetic use”, presented at the American Academy of Dermatology Summer Meeting, July 28- August 1, 2004, New York, NY.

Dolianitis, Con, et al. "Iontophoresis with glycopyrrolate for the treatment of palmoplantar hyperhidrosis". Australasian Journal of Dermatology 45 (2004): 208-212.

Kavanagh, G.M., et al. “Botox® delivery by iontophoresis”. British Journal of Dermatology 151 (2004): 1093-1095.

Ojimba, T.A. & Cameron, A.E.P. “Drawbacks of endoscopic thoracic sympathectomy”. British Journal of Surgery 91 (2004): 264-269.

Hund, Martina, et al. “Randomised, placebo-controlled, double blind clinical trial for the evaluation of the efficacy and safety of oral methanthelinium bromide (Vagantin®) in the treatment of focal hyperhidrosis”. JDDG;2004· 2:343-349. (English, without graphs)

Hund, Martina, et al. “Randomised, placebo-controlled, double blind clinical trial for the evaluation of the efficacy and safety of oral methanthelinium bromide (Vagantin®) in the treatment of focal hyperhidrosis”. JDDG;2004· 2:343-349. (German, with graphs)

Hexsel, Doris Maria MD, et al. “Inguinal, or hexsel’s hyperhidrosis”. Clinics in Dermatology 22 (2004): 53-59.

2003 studies

Atkinson, John L.D. MD & Fealey, Robert D. MD. “Sympathotomy instead of sympathectomy for palmar hyperhidrosis: minimizing postoperative compensatory hyperhidrosis”. Mayo Clinic Proceedings 78:2 (2003): 167-172.

Gossot, Dominique MD, et al. “Long-term results of endoscopic thoracic sympathectomy for upper limb hyperhidrosis”. Ann Thoracic Surg 75 (2003): 1075-1079.

Naumann, M. MD, et al. “Botulinum toxin type A is a safe and effective treatment for axillary hyperhidrosis over 16 months”. Arch Dermatol 139 (2003): 731-736.

Connolly, Maureen & de Berker, David. "Management of primary hyperhidrosis". Am J Clin Dermatol 4:10 (2003): 681-697.

Kaufmann, Horacio, et al. “Primary hyperhidrosis”. Clin Auton Res 13 (2003): 96-98.

2002 studies

Karakoç, Y, et al. “Safe control of palmoplantar hyperhidrosis with direct electrical current.” Int J Dermatol 41 (2002): 602-605. (Abstract Only)

Tögel, B, et al. “Current therapeutic strategies for hyperhidrosis: a review.” Eur J Dermatol 12 (2002):  219-223. (Abstract Only)

Atkins, JL & Butler, PE.  “Hyperhidrosis:  a review of current management.” Plast Reconstr Surg 110 (2002):  222-228.  (Abstract Only)

Ackerl, K, et al. “The scent of fear”. Neuro Endocrinol Lett 23:2 (2002): 79-84. (Abstract Only)

Tan, Stephen R. MD & Solish, Nowell MD, FRCPC. “Long-term efficacy and quality of life in the treatment of focal hyperhidrosis with botulinum toxin A”. Dermatol Surg 28:6 (2002): 495-499.

Davidson, Jonathan R.T., et al. “Hyperhidrosis in social anxiety disorder”. Progress in Neuro-Psychopharmacology & Biological Psychiatry 26 (2002): 1327-1331.

Naumann, M.K., et al. “Effect of botulinum toxin type A on quality of life measures in patients with excessive axillary sweating: a randomized controlled trial”. Brit J Dermatol 147 (2002): 1218-1226.

2001 studies

Naumann, M. & Lowe, N.J. “Botulinum toxin type A in treatment of bilateral primary axillary hyperhidrosis: randomized, parallel group, double blind, placebo controlled trial”. BMJ 323 (2001): 596-599.

2000 studies

Kinkelin, I., et al. “Effective treatment of frontal hyperhidrosis with botulinum toxin A”. British Journal of Dermatology 143:4 (2000): 824-827.

Swinehart, James M. MD. "Treatment of axillary hyperhidrosis: combination of the starch-iodine test with the tumescent liposuction technique". Dermatol Surg 26 (2000): 392-396

1998 studies

Glogau, RG.  “Botulinum A neurotoxin for axillary hyperhidrosis.  No sweat Botox.”  Dermatol Surg 24 (1998):  817-819. (Abstract Only)

Benohanian, Antranik MD, FRCPC, et al. "Localized hyperhidrosis treated with aluminum chloride in a salicylic acid gel base". International Journal of Dermatology 37 (1998): 701-703.

Stolman, Lewis P. MD, FRCP(C). "Treatment of hyperhidrosis". Dermatologic Clinics 16:4 (October 1998): 863-867.

1993 studies

Kirschbaum, C, et al. “The ‘Trier Social Stress Test’ – a tool for investigating psychobiological stress responses in a laboratory setting”. Neuropsychobiology 28: 1-2 (1993): 76-81. (Abstract Only)

1989 studies

Dahl, JC & Glent-Madsen, L. “Treatment of hyperhidrosis manuum by tap water iontophoresis.” Acta Derm Venereol 69 (1989): 346-348.  (Abstract Only)

1988 studies

Glent-Madsen, L & Dahl, JC. “Axillary hyperhidrosis: local treatment with aluminum-chloride hexahydrate 25% in absolute ethanol with and without supplementary treatment with triethanolamine.” Acta Derm Venereol 68 (1988): 87-89. (Abstract Only)

1987 studies

Stolman, Lewis P. MD, FRCP (C). "Treatment of excess sweating of the palms by iontophoresis". Arch Dermatol 123 (July 1987): 893-896.

1986 studies

White, JW Jr. “Treatment of primary hyperhidrosis.” Mayo Clin Proc 61 (1986):  951-956. (Abstract Only)

1984 studies

Hölzle, E & Braun-Falco, O.  “Structural changes in axillary eccrine glands following long-term treatment with aluminum chloride hexahydrate solution.”  Br J Dermatol 110 (1984):  399-403.  (Abstract Only)

1981 studies

Hill, AC, et al. “Mechanism of action of iontophoresis in the treatment of palmar hyperhidrosis.” Cutis 28 (1981): 69-70,72.  (Abstract Only)

1980 studies

Levit, Fred MD. "Treatment of hyperhidrosis by tap water iontophoresis". Cutis 26 (August 1980): 192-194.

1978 studies

Hays, LL. “The Frey syndrome: a review and double blind evaluation of the topical use of a new anticholinergic agent.” Laryngoscope 88 (1978): 1796-1824.  (Abstract Only)

1977 studies

Adar, R, et al. “Palmar hyperhidrosis and its surgical treatment: a report of 100 cases.” Ann Surg 186 (1977):  34-41. (Abstract Only)

1951 studies

Bouman, HD & Lentzer, EM. “The treatment of hyperhidrosis of hands and feet with constant current.” Am J Phys Med 31 (1952): 158-169. (Abstract Only)

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