It's vital to review published clinical data when discussing or reporting on health and hyperhidrosis. Further, we strongly encourage product and treatment development teams to conduct rigorous testing and to espouse¬†only that which can be validated.
The articles, posters, and study data provided chronologically below represents the best¬†peer-reviewed¬†medical and scientific information to date regarding the physiology, treatment, and effects of hyperhidrosis. New data and results will be posted as they become available. Use this rich library of research to inform your decisions and perceptions.
If you know of published scientific information that should be included here, please let us know.
Biehle-Hulette, Susan J. PhD, et al.¬† ‚ÄúSignificant protection from event sweat ‚Äď without a prescription‚ÄĚ, presented at the American Academy of Dermatology 71st Annual Meeting, March 1-5, 2013, Miami Beach, FL .
Hong, H. Chih-Ho MD, FRCPC, et al.¬† ‚ÄúClinical evaluation of a microwave device for treating axillary hyperhidrosis‚ÄĚ.¬† Dermatol Surg doi:¬† 10.1111/j.1524-4725.2012.02375.x.¬† Published online March 27, 2012.
Walling, Hobart W. MD, PhD.¬† ‚ÄúSystemic therapy for primary hyperhidrosis:¬† a retrospective study of 59 patients treated with glycopyrrolate or clonidine‚ÄĚ.¬† J Am Acad Dermatol 66:3 (2012):¬† 387-392.
Wolosker, Nelson MD, et al.¬† ‚ÄúEvaluation of quality of life over time among 453 patients with hyperhidrosis submitted to endoscopic thoracic sympathectomy‚ÄĚ.¬† Journal of Vascular Surgery 55:1 (2012):¬† 154-156.
Salvaggio, Heather L. MD & Wagner, Annette M. MD.¬† ‚ÄúSuture boots:¬† an aid for the injection of onabotulinum toxin A for primary focal hyperhidrosis‚ÄĚ.¬† Pediatric Dermatology doi:¬† 10.1111/j.1525-1470.2012.01849.x.¬† Published online September 7, 2012.
Swaile, D.F., et al.¬† ‚ÄúClinical studies of sweat rate reduction by an over-the-counter soft-solid antiperspirant and comparison with a prescription antiperspirant product in male panelists‚ÄĚ.¬† Br J Dermatol¬† 166 Suppl. 1 (2012):¬† 22-26.
Wang, Fei-ge, et al.¬† ‚ÄúComparison of compensatory sweating and quality of life following thoracic sympathetic block for palmar hyperhidrosis:¬† electrocautery hook versus titanium clip‚ÄĚ.¬† Chinese Medical Journal 124:21 (2011):¬† 3495-3498.
Atkinson, John L.D. MD, et al.¬† ‚ÄúEndoscopic transthoracic limited sympathotomy for palmar-plantar hyperhidrosis:¬† outcomes and complications during a 10-year period‚ÄĚ.¬† Mayo Clin Proc 86:8 (2011):¬† 721-729.
Woolery-Lloyd, Heather MD & Valins, Whitney MD.¬† ‚ÄúAluminum chloride hexahydrate in a salicylic acid gel base: a case series of combination therapy with botulinum toxin type A for moderate to severe hyperhidrosis‚ÄĚ. Cutis 88:1 (2011):¬† 43-45.
Doft, MA, et al. "Treatment of axillary hyperhidrosis with botulinum toxin: a single surgeon's experience with 53 consecutive patients". Aesthetic Plast Surg 2011 May 11. (Abstract Only)
Lupin, Mark, et al. "A multi-center evaluation of the miradry system to treat subjects with axillary hyperhidrosis", presented at the 31st ASLMS Annual Conference, April 1-3, 2011, Grapevine, TX.
Kilmer, Suzanne, et al. "A randomized, blinded clinical study of a microwave device for treatment of axillary hyperhidrosis", presented at the 31st ASLMS Annual Conference, April 1-3, 2011, Grapevine, TX.
Marques, Andrea H., et al.¬† ‚ÄúEvaluation of stress symptoms by applying noninvasive methodologies:¬† measurements of neuroimmune biomarkers in the sweat, heart rate variability and salivary cortisol‚ÄĚ.¬† Neuroimmunomodulation 17:3 (2010):¬† 205-208.
Cantarella, Giovanna MD, et al.¬† ‚ÄúTreatment of Frey‚Äôs syndrome with botulinum toxin B‚ÄĚ.¬† Otolaryngol Head Neck Surg 143 (2010):¬† 214-218.
Glaser, Dee Anna, MD, et al. "A randomized, blinded clinical evaluation of a novel microwave device for treatment of axillary hyperhidrosis", presented at the 2010 ASDS/ASCDAS Joint Annual Meeting, October 21-24, 2010, Chicago, IL.
Hill, Samantha MD. (Fall 2010). "Hyperhidrosis Diagnosis and Management". Pediatric Rounds, a newsletter from the physicians of Children's Specialty Group, 12-14.
Shams, Kave MBChB, MRCP & Kavanagh, Gina M. MBChB, MRCP. "Immediate reduction in sweat secretion with electric current application in primary palmar hyperhidrosis". Archdermatol doi: 10.1001/archdermatol.2010.300. Published online October 18, 2010.
Milanez de Campos, Jose Ribas, et al.¬† ‚ÄúComparison of pain severity following video-assisted thoracoscopic sympathectomy:¬† electric versus harmonic scalpels‚ÄĚ.¬† Interactive Cardiovascular and Thoracic Surgery 10 (2010):¬† 919-922.
Wolosker, Nelson, MD, PhD, et al.¬† ‚ÄúQuality of life before surgery is a predictive factor for satisfaction among patients undergoing sympathectomy to treat hyperhidrosis‚ÄĚ.¬† Journal of Vascular Surgery 51:5 (2010):¬† 1190-1194.
Mujica-Parodi, Lilianne R., et al.¬† ‚ÄúChemosensory cues to conspecific emotional stress activate amygdale in humans‚ÄĚ.¬† PLoS One doi:¬† 10.1371/journal.pone.0006415.¬† Published online July 29, 2009.
¬†Prehn-Kristensen, A, et al.¬† ‚ÄúInduction of empathy by the smell of anxiety‚ÄĚ.¬† PLoS One doi:¬† 10.1371/journal.pone.0005987.¬† Published online June 24, 2009.
Flanagan, Katherine H. MD & Glaser, Dee Anna MD.¬† ‚ÄúAn open-label trial of the efficacy of 15% aluminum chloride in 2% salicylic acid gel base in the treatment of moderate-to-severe primary axillary hyperhidrosis‚ÄĚ. Journal of Drugs in Dermatology 8:5 (2009):¬† 477-480.
Jones, Terry MD, et al. "Safety and tolerability of topical botulinum toxin type A in healthy adults", presented at the 69th Annual Meeting of the Society for Investigative Dermatology, May 2009, Montreal, Canada.
‚ÄúAmerican Academy of Dermatology Responds to FDA Decision Regarding Botulinum Toxin Products‚ÄĚ, Schaumburg, IL, April 2009.
Walling, Hobart W. MD, PhD. ‚ÄúPrimary hyperhidrosis increases the risk of cutaneous infection: a case-control study of 387 patients‚ÄĚ. J Am Acad Dermatol doi: 10.1016/j.jaad.2009.02.038. Published online April 24, 2009.
Keller, Steven M., et al. ‚ÄúDiagnosis of palmar hyperhidrosis via questionnaire without physical examination‚ÄĚ. Clin Auton Res doi: 10.1007/s10286-009-0006-5. Published online April 16, 2009.
Grunfeld, Alexander, et al. ‚ÄúBotulinum toxin for hyperhidrosis‚ÄĚ. Am J Clin Dermatol 10:2 (2009): 87-102.
Miller, Daniel L. MD, et al. ‚ÄúEffect of sympathectomy level on the incidence of compensatory hyperhidrosis after sympathectomy for palmar hyperhidrosis‚ÄĚ. J Thorac Cardiovasc Surg 138 (2009): 581-585. (Abstract Only)
Cruz, Jorge MD, PhD, et al. ‚ÄúEffects of endoscopic thoracic sympathectomy for primary hyperhidrosis on cardiac autonomic nervous activity‚ÄĚ. The Journal of Thoracic and Cardiovascular Surgery 137:3 (2009): 664-669.
Chow, A & Wilder-Smith, E.P. ‚ÄúEffect of transdermal botulinum toxin on sweat secretion in subjects with idiopathic palmar hyperhidrosis‚ÄĚ. Br J Dermatol 160:3 (2009): 721-722.
Gelbard, Christina M. MD, et al. ‚ÄúPrimary pediatric hyperhidrosis: a review of current treatment options‚ÄĚ. Pediatric Dermatology 25:6 (2008): 591-598.
Kossintseva, Iren & Barankin, Benjamin. ‚ÄúImprovement in both raynaud disease and hyperhidrosis in response to botulinum toxin type A treatment‚ÄĚ. Journal of Cutaneous Medicine and Surgery 12:4 (2008): 189-193.
Efthymiou, Christopher Andrew & Thorpe, James Andrew Charles. ‚ÄúCompensatory hyperhidrosis: a consequence of truncal sympathectomy treated by video assisted application of botulinum toxin and reoperation‚ÄĚ. European Journal of Cardio-thoracic Surgery 33 (2008): 1157-1158.
Hartl, DM, et al. ‚ÄúBotulinum toxin A for quality of life improvement in post-parotidectomy gustatory sweating (Frey‚Äôs syndrome)‚ÄĚ. The Journal of Laryngology & Otology 122 (2008): 1100-1104.
Honeyman, JF, et al. ‚ÄúEfficacy of botulinum toxin for a congenital eccrine naevus‚ÄĚ. J Eur Acad Dermatol Venereol 22:10 (2008): 1275-1276.
Flanagan, Katherine H. MD, et al. ‚ÄúBotulinum toxin type A versus topical 20% aluminum chloride for the treatment of moderate to severe primary focal axillary hyperhidrosis‚ÄĚ. Journal of Drugs in Dermatology 7:3 (2008): 221-227.
Smalls, Lola Kelly PhD, MBA, et al. ‚ÄúClinical comparison of otc products labeled prescription strength wetness protection to prescription antiperspirants‚ÄĚ, presented at the 66th Annual Meeting of the American Academy of Dermatology, February 1-5, 2008, San Antonio, TX.
Smalls, Lola Kelly PhD, MBA, et. al. ‚ÄúChromophore mapping of hemoglobin for the assessment of axillary irritation: comparison of otc and prescription antiperspirants‚ÄĚ, presented at the 66th Annual Meeting of the American Academy of Dermatology, February 1-5, 2008, San Antonio, TX.
de Bree, Remco MD, PhD, et al.¬† ‚ÄúManagement of Frey syndrome‚ÄĚ.¬† Head & Neck 29:8 (2007):¬† 773-778.
Na, Gun Yoen MD, et al. "Control of palmar hyperhidrosis with a new 'dry-type' iontophoretic device". Dermatol Surg 33 (2007): 57-61.
Solish, Nowell MD, FRCPC, et al. ‚ÄúA comprehensive approach to the recognition, diagnosis, and severity-based treatment of focal hyperhidrosis: recommendations of the canadian hyperhidrosis advisory committee". Dermatol Surg 33 (2007): 908-923.
Bechara, Falk G. MD, et al. ‚ÄúFocal hyperhidrosis of the anal fold: successful treatment with botulinum toxin A‚ÄĚ. Dermatol Surg 33 (2007): 924-927.
NAD Examines Advertising for P&G's 'Secret Clinical Strength,' National Advertising Review Council, New York, NY, July 2007.
Glaser, Dee Anna MD, et al. ‚ÄúPrimary focal hyperhidrosis: scope of the problem‚ÄĚ. Cutis 79:suppl 5 (2007): 5-17.
Glaser, Dee Anna MD, et al. ‚ÄúPalmar and plantar hyperhidrosis: best practice recommendations and special considerations‚ÄĚ. Cutis 79:suppl 5 (2007): 18-28.
Glaser, Dee Anna MD, et al. ‚ÄúFacial hyperhidrosis: best practice and recommendations and special considerations‚ÄĚ. Cutis 79:suppl 5 (2007): 29-32.
Ram, Ramin MD, et al. ‚ÄúCurrent and emerging therapeutic modalities for hyperhidrosis, part 2: moderately invasive and invasive procedures‚ÄĚ. Cosmetic Dermatology 79 (2007): 281-288.
Glaser, Dee Anna MD, et al. ‚ÄúFunctional and dermatology-specific quality of life benefits with repeated botulinum toxin type A treatment of primary axillary hyperhidrosis over 4 years‚ÄĚ, presented at the 65th Annual Meeting of the American Academy of Dermatology, February 2-6, 2007, Washington, DC.
Kessler, Edward, B.A., et al. ‚ÄúA demographical study of hyperhidrosis‚ÄĚ, presented at the 65th Annual Meeting of the American Academy of Dermatology, February 2-6, 2007, Washington, DC.
Glaser, Dee Anna MD, et al. ‚Äú4-Year longitudinal data on the efficacy and safety of repeated botulinum toxin type A therapy for primary axillary hyperhidrosis‚ÄĚ, presented at the 65th Annual Meeting of the American Academy of Dermatology, February 2-6, 2007, Washington, DC.
Thomas, Mike BS, MBA, et al. ‚ÄúAlternative topical treatment to an aluminum chloride antiperspirant that provides prescription strength efficacy with significantly less irritation‚ÄĚ, presented at the 65th Annual Meeting of the American Academy of Dermatology, February 2-6, 2007, Washington, DC.
Aghaei, Shahin MD. ‚ÄúBotulinum toxin therapy for palmar hyperhidrosis: experience in an Iranian population‚ÄĚ. The International Society of Dermatology 46 (2007): 212-214.
Lear, William BSC, MD, et al. ‚ÄúAn epidemiological study of hyperhidrosis‚ÄĚ. Dermatol Surg 33 (2007): S69-S75.
Talarico-Filho, Sergio MD, et al. ‚ÄúA double-blind, randomized, comparative study of two type A botulinum toxins in the treatment of primary axillary hyperhidrosis‚ÄĚ. Dermatol Surg 33 (2007): S44-S50.
Glogau, Richard G. MD. "Topically applied botulinum toxin type A for the treatment of primary axillary hyperhidrosis: results of a randomized, blinded, vehicle-controlled study". Dermatol Surg 33 (2007): S76-S80.
Milanez de Campos, Jose Ribas, et al.¬† ‚ÄúAxillary hyperhidrosis:¬† T3/T4 versus T4 thoracic sympathectomy in a series of 276 cases‚ÄĚ.¬† Journal of Laparoendoscopic & Advanced Surgical Techniques 16:6 (2006):¬† 598-603.
Barankin, Benjamin MD, et al. ‚ÄúTreatment of inguinal hyperhidrosis with botulinum toxin type A‚ÄĚ. International Journal of Dermatology 45 (2006): 985-986.
Kavanagh, Gina M. MD & Shams, Kave MD. ‚ÄúBotulinum toxin type A by iontophoresis for primary palmar hyperhidrosis‚ÄĚ. Journal of the American Academy of Dermatology 55:5 (2006): S115-S117.
Kavanagh, G.M., et al. ‚ÄúTopical glycopyrrolate should not be overlooked in treatment of focal hyperhidrosis‚ÄĚ. British Journal of Dermatology 155:2 (2006): 487.
Pariser, David MD, et al. ‚ÄúEffect of botulinum toxin type A treatment for severe primary axillary hyperhidrosis on work performance and productivity: results from an open-label clinical study‚ÄĚ, presented at the 64th Annual Meeting of the American Academy of Dermatology, March 3-7, 2006, San Francisco, CA.
Thomas, Mike MBA, et al. ‚ÄúPanel discussions among hyperhidrosis patients to assess lifestyle limitations, treatment regimes, and compensating behaviors‚ÄĚ, presented at the 64th Annual Meeting of the American Academy of Dermatology, March 3-7, 2006, San Francisco, CA.
Hamm, Henning, et al. "Primary focal hyperhidrosis: disease characteristics and functional impairment". Dermatology 2006 212 (2006): 343-353.
Moya, J., et al.‚ÄúThoracic sympathicolysis for primary hyperhidrosis‚ÄĚ. Surg Endosc 20 (2006): 598-602.
Ogata, A, et al.¬† ‚ÄúLow and high frequency acupuncture stimulation inhibits mental stress-induced sweating in humans via different mechanisms‚ÄĚ.¬† Auton Neurosci 118:¬† 1-2 (2005):¬† 93-101.¬† (Abstract Only)
Glaser, Dee Anna MD, et al. ‚ÄúEfficacy and safety of repeated botulinum toxin type A treatment for primary axillary hyperhidrosis: 12-month interim analysis of a multicenter, open-label trial‚ÄĚ, presented at ACADEMY ‚Äô05 American Academy of Dermatology Summer Meeting, July 20-24, 2005, Chicago, IL.
Kowalski, Jonathan W. PharmD, MS, et al. ‚ÄúCost-effectiveness and budget impact of botulinum toxin type A (BoNTA) treatment for severe primary axillary hyperhidrosis inadequately managed with topical agents‚ÄĚ, presented at ACADEMY ‚Äô05 American Academy of Dermatology Summer Meeting, July 20-24, 2005, Chicago, IL.
Neumayer, Christoph MD, et al. "Effect of endoscopic thoracic sympathetic block on plantar hyperhidrosis". Arch Surg 140: 676-680 (2005).
Eisenach, John H. MD, et al. ‚ÄúHyperhidrosis: evolving therapies for a well-established phenomenon‚ÄĚ. Mayo Clinic Proceedings 80:5 (2005): 657-666.
Solish, Nowell MD, et al. ‚ÄúProspective open-label study of botulinum toxin type A in patients with axillary hyperhidrosis: effects on functional impairment and quality of life‚ÄĚ. Dermatol Surg 31:4 (2005): 405-413.
Cliff, Sandeep H. FRCP & Reeken, Saskia. ‚ÄúAxillary hyperhidrosis and botox responding to demands: starting a nurse-led service‚ÄĚ. Nurse2Nurse 5:1 (2005): 28-30.
Krogstad, AL, et al. "No compensatory sweating after botulinum toxin treatment of palmar hyperhidrosis". Br J Dermatol 152:2 (Feb 2005): 329-333. (Abstract Only)
Haider, Aamir & Solish, Nowell.‚ÄúFocal hyperhidrosis: diagnosis and management‚ÄĚ. CMAJ 172:1 (2005): 1-7.
Lowe, N, et al. "The place of botulinum toxin type A in the treatment of focal hyperhidrosis". Br J Dermatol 151:6 (Dec 2004): 1115-1122. (Abstract Only)
Lee, Jae-Bong MD, et al. ‚ÄúA case of foul genital odor treated with botulinum toxin A‚ÄĚ. Dermatologic Surgery doi: 10.1111/j.1524-4725.2004.30382.x. Published online September 1, 2004. (Abstract Only)
Campanati, Anna MD, et al. ‚ÄúLocal neural block at the wrist for treatment of palmar hyperhidrosis with botulinum toxin: technical improvements‚ÄĚ. Journal of the American Academy of Dermatology 51:3 (2004): 345-348.
Strutton, David R. PhD, MPH, et al. ‚ÄúUS prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey‚ÄĚ. Journal of the American Academy of Dermatology 51:2 (2004): 241-248.
Hornberger, John MD, MS, et al. ‚ÄúRecognition, diagnosis, and treatment of primary focal hyperhidrosis‚ÄĚ. Journal of the American Academy of Dermatology 51:2 (2004): 274-286.
Glaser, DA, et al. ‚ÄúBotulinum toxin type A improves occupational impairment associated with primary axillary hyperhidrosis and results in high levels of satisfaction with treatment‚ÄĚ, presented at the American Academy of Dermatology Summer Meeting, July 28- August 1, 2004, New York, NY.
Carruthers, Alastair MD & Carruthers, Jean MD. ‚ÄúLong-term safety review of subjects treated with botulinum toxin type A for cosmetic use‚ÄĚ, presented at the American Academy of Dermatology Summer Meeting, July 28- August 1, 2004, New York, NY.
Dolianitis, Con, et al.¬† "Iontophoresis with glycopyrrolate for the treatment of palmoplantar hyperhidrosis".¬† Australasian Journal of Dermatology 45 (2004):¬† 208-212.
Kavanagh, G.M., et al. ‚ÄúBotox¬ģ delivery by iontophoresis‚ÄĚ. British Journal of Dermatology 151 (2004): 1093-1095.
Ojimba, T.A. & Cameron, A.E.P. ‚ÄúDrawbacks of endoscopic thoracic sympathectomy‚ÄĚ. British Journal of Surgery 91 (2004): 264-269.
Hund, Martina, et al. ‚ÄúRandomised, placebo-controlled, double blind clinical trial for the evaluation of the efficacy and safety of oral methanthelinium bromide (Vagantin¬ģ) in the treatment of focal hyperhidrosis‚ÄĚ. JDDG;2004¬∑ 2:343-349. (English, without graphs)
Hund, Martina, et al. ‚ÄúRandomised, placebo-controlled, double blind clinical trial for the evaluation of the efficacy and safety of oral methanthelinium bromide (Vagantin¬ģ) in the treatment of focal hyperhidrosis‚ÄĚ. JDDG;2004¬∑ 2:343-349. (German, with graphs)
Hexsel, Doris Maria MD, et al. ‚ÄúInguinal, or hexsel‚Äôs hyperhidrosis‚ÄĚ. Clinics in Dermatology 22 (2004): 53-59.
Atkinson, John L.D. MD & Fealey, Robert D. MD. ‚ÄúSympathotomy instead of sympathectomy for palmar hyperhidrosis: minimizing postoperative compensatory hyperhidrosis‚ÄĚ. Mayo Clinic Proceedings 78:2 (2003): 167-172.
Gossot, Dominique MD, et al. ‚ÄúLong-term results of endoscopic thoracic sympathectomy for upper limb hyperhidrosis‚ÄĚ. Ann Thoracic Surg 75 (2003): 1075-1079.
Naumann, M. MD, et al. ‚ÄúBotulinum toxin type A is a safe and effective treatment for axillary hyperhidrosis over 16 months‚ÄĚ. Arch Dermatol 139 (2003): 731-736.
Connolly, Maureen & de Berker, David.¬† "Management of primary hyperhidrosis".¬† Am J Clin Dermatol 4:10 (2003):¬† 681-697.
Kaufmann, Horacio, et al. ‚ÄúPrimary hyperhidrosis‚ÄĚ. Clin Auton Res 13 (2003): 96-98.
Tan, Stephen R. MD & Solish, Nowell MD, FRCPC. ‚ÄúLong-term efficacy and quality of life in the treatment of focal hyperhidrosis with botulinum toxin A‚ÄĚ. Dermatol Surg 28:6 (2002): 495-499.
Davidson, Jonathan R.T., et al. ‚ÄúHyperhidrosis in social anxiety disorder‚ÄĚ. Progress in Neuro-Psychopharmacology & Biological Psychiatry 26 (2002): 1327-1331.
Naumann, M.K., et al. ‚ÄúEffect of botulinum toxin type A on quality of life measures in patients with excessive axillary sweating: a randomized controlled trial‚ÄĚ. Brit J Dermatol 147 (2002): 1218-1226.
Naumann, M. & Lowe, N.J. ‚ÄúBotulinum toxin type A in treatment of bilateral primary axillary hyperhidrosis: randomized, parallel group, double blind, placebo controlled trial‚ÄĚ. BMJ 323 (2001): 596-599.
Kirschbaum, C, et al.¬† ‚ÄúThe ‚ÄėTrier Social Stress Test‚Äô ‚Äď a tool for investigating psychobiological stress responses in a laboratory setting‚ÄĚ.¬† Neuropsychobiology 28:¬† 1-2 (1993):¬† 76-81.¬† (Abstract Only)