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Systemic Medication: Propantheline for hyperhidrosis in spinal cord injury
The autonomic dysreflexia seen in patients often years after
spinal cord injury can often lead to hyperhidrosis.[25]
Two patients with quadriplegia had excellent control of excessive
sweating with use of the anticholinergic propantheline. When
used at doses that treat neurogenic bladder, also seen in
spinal cord injury, propantheline can be expected to also
block the cholinergic receptors involved in sweat gland stimulation.
Another agent found useful for treating the hyperhidrosis
associated with spinal cord injury is the opioid propoxyphene.[142]
Two patients with excessive sweating due to spinal injury
of different duration and location had a dramatic reduction
in sweating when given propoxyphene. Propoxyphene may work
by a weak ganglionic blocking agent, reducing sympathetic
tone to the eccrine sweat glands.
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