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Systemic Medication: Indomethacin for generalized hyperhidrosis
A 61-year-old woman had lifelong generalized hyperhidrosis
that had been worsening over 4 to 6 months, with severe night
sweats and no signs of any systemic disease underlying her
symptoms.[144]
Coincidental treatment of arthritis with indomethacin 25 mg
3 times a day relieved her excessive sweating, which returned
when indomethacin was discontinued. These findings led to
speculation that prostaglandins may be involved in the regulation
of sweating.
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