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Systemic Medication: Clonidine for facial and paroxysmal localized hyperhidrosis
Clonidine is a centrally active alpha-2 receptor agonist
that decreases norepinephrine release.[79]
Clonidine reduced sweating in 2 women with paroxysmal localized
hyperhidrosis, a rare condition that can be idiopathic, can
be due to nervous system disease, or can occur as a manifestation
of gustatory sweating.[79]
A patient with excessive sweating due to tricyclic antidepressant
use had marked reduction in sweating with clonidine.[36]
In another report, a man with anxiety-induced facial and scalp
hyperhidrosis found relief with the combination of clonidine
and topical aluminum chloride.[146]
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